{ "_id": "6a59ef8809eb0996dd68fa79", "Package": "sp23design", "Type": "Package", "Title": "Design and Simulation of Seamless Phase II-III Clinical Trials", "Version": "0.9-1", "Date": "2022-04-18", "Authors@R": "c(\nperson(\"Balasubramanian\", \"Narasimhan\",\nemail = \"naras@stat.stanford.edu\", role = c(\"aut\", \"cre\")),\nperson(\"Mei-Chiung\", \"Shih\",\nemail = \"meichiun@stanford.edu\", role = \"aut\"),\nperson(\"Pei\", \"He\",\nemail = \"he.pei.hepei@gmail.com\", role = \"aut\"))", "Author": "Balasubramanian Narasimhan [aut, cre], Mei-Chiung Shih [aut],\nPei He [aut]", "Maintainer": "Balasubramanian Narasimhan ", "Description": "Provides methods for generating, exploring and executing\nseamless Phase II-III designs of Lai, Lavori and Shih using\ngeneralized likelihood ratio statistics. Includes pdf and\nsource files that describe the entire R implementation with the\nrelevant mathematical details.", "License": "LGPL-3", "NeedsCompilation": "no", "Packaged": { "Date": "2026-07-17 08:58:22 UTC", "User": "root" }, "Repository": "https://hrpcisd.r-universe.dev", "Date/Publication": "2022-04-19 09:00:02 UTC", "RemoteUrl": "https://github.com/cran/sp23design", "RemoteRef": "HEAD", "RemoteSha": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "_user": "hrpcisd", "_type": "src", "_file": "sp23design_0.9-1.tar.gz", "_fileid": "https://r2.ropensci.org/09bf255b6279a93cbda479a66208c3070e2ab073b66c7c616ab79128efab697e", "_filesize": 535756, "_sha256": "09bf255b6279a93cbda479a66208c3070e2ab073b66c7c616ab79128efab697e", "_expires": "2026-10-25T09:01:58.000Z", "_created": "2026-07-17T08:58:22.000Z", "_published": "2026-07-17T09:02:00.646Z", "_jobs": [ { "job": 87845904782, "time": 125, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "8402051792" }, { "job": 87845904813, "time": 126, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "8402052401" }, { "job": 87845904790, "time": 136, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "8402047363" }, { "job": 87845904779, "time": 171, "config": "macos-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "8402056385" }, { "job": 87845268092, "time": 204, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "8402001736" }, { "job": 87845904748, "time": 119, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "8402049552" }, { "job": 87845904786, "time": 72, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "8402031095" }, { "job": 87845904791, "time": 73, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "8402031261" }, { "job": 87845904837, "time": 87, "config": "windows-release", "r": "4.6.1", "check": "OK", "artifact": "8402036758" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976", "_status": "success", "_upstream": "https://github.com/cran/sp23design", "_commit": { "id": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "author": "Balasubramanian Narasimhan ", "committer": "cran-robot ", "message": "version 0.9-1\n", "time": 1650358802 }, "_maintainer": { "name": "Balasubramanian Narasimhan", "email": "naras@stat.stanford.edu", "login": "hrpcisd", "description": "", "uuid": 10241099 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.0", "role": "Depends" }, { "package": "mvtnorm", "role": "Imports" }, { "package": "survival", "role": "Imports" }, { "package": "RUnit", "role": "Suggests" } ], "_owner": "cran", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "hrpcisd", "count": 2, "uuid": 10241099 } ], "_userbio": { "uuid": 10241099, "type": "user", "name": "hrpcisd", "followers": 2 }, "_downloads": { "count": 271, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/sp23design" }, "_searchresults": 26, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/sp23design.html", "manual.pdf" ], "_realowner": "hrpcisd", "_cranurl": false, "_releases": [ { "version": "0.9", "date": "2014-06-25" }, { "version": "0.9-1", "date": "2022-04-19" } ], "_exports": [ "computeResponseSummary", "executeSP23Design", "exploreSP23Design", "generateClinicalTrialData", "generateInterimData", "generateSP23Design", "performInterimLook", "resetSP23Design" ], "_help": [ { "page": "sp23design-package", "title": "sp23design: A package for the design, exploration and execution of seamless Phase II-II clinical trials", "topics": [ "sp23design-package", "sp23design" ] }, { "page": "analyzeSP23Design", "title": "Analyses the results of running a design. If a trial history, such as the result of the function 'executeSP23Design' or a history of the actual conduct of a single trial is provided, it returns the analysis results.", "topics": [ "analyzeSP23Design" ] }, { "page": "computeDGivenXi", "title": "Given the estimates of the pi and theta, compute d.", "topics": [ "computeDGivenXi" ] }, { "page": "computeGammaSubT", "title": "Compute the estimate of the variance of the generalized likelihood ratio statistic at time t", "topics": [ "computeGammaSubT" ] }, { "page": "computeResponseSummary", "title": "Given interim data, compute the response end-point summary", "topics": [ "computeResponseSummary" ] }, { "page": "executeSP23Design", "title": "Given a design object, interim data and the current calendar time, conduct the interim analysis for the time", "topics": [ "executeSP23Design" ] }, { "page": "exploreSP23Design", "title": "Explore a specified design by simulation", "topics": [ "exploreSP23Design" ] }, { "page": "generateClinicalTrialData", "title": "A function to generate some clinical trial data according the joint model of response and survival for simulations", "topics": [ "generateClinicalTrialData" ] }, { "page": "generateInterimData", "title": "Generate interim data for a clinical trial from a data set.", "topics": [ "generateInterimData" ] }, { "page": "generateSP23Design", "title": "Generate a seamless Phase II-III design object given some the true parameters and clinical trial parameters", "topics": [ "generateSP23Design" ] }, { "page": "hessian", "title": "A utility function to compute the hessian of the generalized (conditional) partial likelihood ratio statistic", "topics": [ "hessian" ] }, { "page": "loglik1", "title": "Compute the response log-likelihood", "topics": [ "loglik1" ] }, { "page": "loglik1GivenDelta", "title": "Computes the constrained response log-likelihood (on the alternative)", "topics": [ "loglik1GivenDelta" ] }, { "page": "loglik2", "title": "Computes the survival log-likelihood", "topics": [ "loglik2" ] }, { "page": "loglik2.repar0", "title": "Computes the constrained survival log-likelihood", "topics": [ "loglik2.repar0" ] }, { "page": "mHP.b", "title": "Compute the modified Haybittle-Peto boundary", "topics": [ "mHP.b" ] }, { "page": "mHP.c", "title": "Compute the modified Haybittle-Peto boundary for the final look", "topics": [ "mHP.c" ] }, { "page": "performInterimLook", "title": "Perform an interim look in a seamless Phase II-III clinical trial", "topics": [ "performInterimLook" ] }, { "page": "resetSP23Design", "title": "Reset the design object so that counts and results are zeroed out", "topics": [ "resetSP23Design" ] }, { "page": "solveForCGivenABD", "title": "A convenience function to reduce dimension by solving for one variable c in terms of others a, b, d", "topics": [ "solveForCGivenABD" ] } ], "_rundeps": [ "lattice", "Matrix", "mvtnorm", "survival" ], "_score": 1.414973347970818, "_indexed": true, "_nocasepkg": "sp23design", "_universes": [ "hrpcisd" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.9-1", "date": "2026-07-17T09:00:23.000Z", "distro": "resolute", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/d349b92e1f3075b7d1e1c4b07f64a61a1596354a595718d5f70f8e9330acf21e", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.6.1", "os": "linux", "version": "0.9-1", "date": "2026-07-17T09:00:24.000Z", "distro": "resolute", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/a2738f9494bcfed819a8dad22e4cbbfd8651f17abea215abe64bbced653cb15f", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.5.3", "os": "mac", "version": "0.9-1", "date": "2026-07-17T09:00:22.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/ac4ce2112979484c8a0d8ac5af903a0645af7e4e3243477bacf8e0560b8641bc", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.6.1", "os": "mac", "version": "0.9-1", "date": "2026-07-17T09:00:36.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/5f3ea9ee465281ef92aca73dffa15a30401c5be53c54f640a53921a600b5b017", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.6.0", "os": "wasm", "version": "0.9-1", "date": "2026-07-17T09:00:42.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/c4d201ccb7e4aeebbfde1a55a10f463c8c0a1600500ccb8f1f458ddbe7d7ec4e", "status": "success", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.7.0", "os": "win", "version": "0.9-1", "date": "2026-07-17T08:59:26.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/34ca343bcb0719f80cf0cb19e88bc2fb9b3022a5e4eee2903bee92a6f67bf2a5", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.5.3", "os": "win", "version": "0.9-1", "date": "2026-07-17T08:59:29.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/3fffa6308d705618cac4946ea99e3cba254c9ec15b2997ed1bfd0c3a1a616708", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" }, { "r": "4.6.1", "os": "win", "version": "0.9-1", "date": "2026-07-17T08:59:40.000Z", "commit": "0a14623a89a27e1a8b1c218eb3fa555036fc7978", "fileid": "https://r2.ropensci.org/0e26378125afeb6ce96aa0d641ba721a3cdeedafe7a5b005ac0d50e4857e4169", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/hrpcisd/actions/runs/29568085976" } ] }