Package: sp23design 0.9-1

sp23design: Design and Simulation of Seamless Phase II-III Clinical Trials

Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.

Authors:Balasubramanian Narasimhan [aut, cre], Mei-Chiung Shih [aut], Pei He [aut]

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sp23design.pdf |sp23design.html✨
sp23design/json (API)

# Install 'sp23design' in R:
install.packages('sp23design', repos = c('https://hrpcisd.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

1.41 score 26 scripts 167 downloads 8 exports 4 dependencies

Last updated 3 years agofrom:0a14623a89. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKOct 25 2024
R-4.5-winOKOct 25 2024
R-4.5-linuxOKOct 25 2024
R-4.4-winOKOct 25 2024
R-4.4-macOKOct 25 2024
R-4.3-winOKOct 25 2024
R-4.3-macOKOct 25 2024

Exports:computeResponseSummaryexecuteSP23DesignexploreSP23DesigngenerateClinicalTrialDatagenerateInterimDatagenerateSP23DesignperformInterimLookresetSP23Design

Dependencies:latticeMatrixmvtnormsurvival

Readme and manuals

Help Manual

Help pageTopics
sp23design: A package for the design, exploration and execution of seamless Phase II-II clinical trialssp23design-package sp23design
Analyses the results of running a design. If a trial history, such as the result of the function 'executeSP23Design' or a history of the actual conduct of a single trial is provided, it returns the analysis results.analyzeSP23Design
Given the estimates of the pi and theta, compute d.computeDGivenXi
Compute the estimate of the variance of the generalized likelihood ratio statistic at time tcomputeGammaSubT
Given interim data, compute the response end-point summarycomputeResponseSummary
Given a design object, interim data and the current calendar time, conduct the interim analysis for the timeexecuteSP23Design
Explore a specified design by simulationexploreSP23Design
A function to generate some clinical trial data according the joint model of response and survival for simulationsgenerateClinicalTrialData
Generate interim data for a clinical trial from a data set.generateInterimData
Generate a seamless Phase II-III design object given some the true parameters and clinical trial parametersgenerateSP23Design
A utility function to compute the hessian of the generalized (conditional) partial likelihood ratio statistichessian
Compute the response log-likelihoodloglik1
Computes the constrained response log-likelihood (on the alternative)loglik1GivenDelta
Computes the survival log-likelihoodloglik2
Computes the constrained survival log-likelihoodloglik2.repar0
Compute the modified Haybittle-Peto boundarymHP.b
Compute the modified Haybittle-Peto boundary for the final lookmHP.c
Perform an interim look in a seamless Phase II-III clinical trialperformInterimLook
Reset the design object so that counts and results are zeroed outresetSP23Design
A convenience function to reduce dimension by solving for one variable c in terms of others a, b, dsolveForCGivenABD